<i>Pseudomonas aeruginosa</i> High-Risk Sequence Type 463 Co-Producing KPC-2 and AFM-1 Carbapenemases, China, 2020–2022

Emergence of KPC-2-producing Pseudomonas aeruginosa sequence type 463 isolates in Hangzhou, China.

Thirty-nine Klebsiella pneumoniae carbapenemase (KPC)-producing Pseudomonas aeruginosa isolates, all exhibiting high-level resistance to carbapenems and other β-lactam antibiotics, were isolated in Hangzhou, China. Molecular epidemiology analysis indicated the presence of two dominant clones, namely, clones A and B, both of which belong to sequence type 463 (ST463). A genetic environment analys...

Emergence of Escherichia coli sequence type 131 isolates producing KPC-2 carbapenemase in China.

Twenty-two KPC-2-producing Escherichia coli isolates were obtained from three hospitals in Hangzhou, China, from 2007 to 2011. One isolate, with OmpC porin deficiency, exhibited high-level carbapenem resistance. Pulsed-field gel electrophoresis showed that few isolates were indistinguishable or closely related. Multilocus sequence typing indicated that sequence type 131 (ST131) was the predomin...

Emergence of Escherichia coli ST131 sub-clone H30 producing VIM-1 and KPC-3 carbapenemases, Italy.

clone over years, even though repeated introductions of mecC-positive isolates cannot be excluded. Finally, the description of divergent but closely related spa types and PFGE patterns among the mecC-positive isolates potentially reflects local microevolution or the circulation of different subclones. No epidemiological link was evidenced between the three colonized farms, neither at the animal...

First isolate of KPC-2-producing Klebsiella pneumonaie sequence type 23 from the Americas.

KPC-2-producing Klebsiella pneumoniae isolates mainly correspond to clonal complex 258 (CC258); however, we describe KPC-2-producing K. pneumoniae isolates belonging to invasive sequence type 23 (ST23). KPC-2 has scarcely been reported to occur in ST23, and this report describes the first isolation of this pathogen in the Americas. Acquisition of resistant markers in virulent clones could mark ...

KPC-2-producing sequence type 11 Klebsiella pneumoniae detected in Taiwan.